Show simple item record

dc.contributor.authorGommer AM
dc.date.accessioned2012-12-12T19:42:58Z
dc.date.available2012-12-12T19:42:58Z
dc.date.issued1991-11-30
dc.identifier319001001
dc.identifier.urihttp://hdl.handle.net/10029/260180
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractThe quality standards with which parmaceutical substances have to comply are provided by pharmacopoeias. Traditionally, experiments on animals are required for the assessment of the biological activity of certain pharmaceutical substances, particularly those of natural origin. Furthermore, animal tests are used to ensure the purity and safety of pharmaceutical substances. This report provides an inventory of the state of affairs in refining and/or replacing animal tests traditionally required and applied for the estimation of potency of hormones and hormonal products. Also the status quo of replacing some general safety tests are discussed. It is concluded that over the past few years a clear tendency towards the replacement of traditional in vivo bioassays could be observed. However, the actual introduction of alternatives is only slowly taking place, mainly for lack of information about the validity of such techniques. The report includes suggestions and recommendations with regard to the development, validation and application of alternative methods.
dc.description.sponsorshipPlatform alternatieven voor dierproeven
dc.format.extent97 p
dc.language.isoen
dc.relation.ispartofRIVM Rapport 319001001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/319001001.html
dc.subject19nl
dc.subject91-4nl
dc.subjectalternatiefnl
dc.subjectidentiteitnl
dc.subjecteuropese farmacopeenl
dc.subjectpyrogeennl
dc.subjectendotoxine; abnormale toxiciteitnl
dc.subjectcalcitoninenl
dc.subjectcorticotropinenl
dc.subjectgonadotropine; humaan groeihormoonnl
dc.subjectinsulinenl
dc.subjectoxytocinenl
dc.subjectalternativenl
dc.subjectidentity; european pharmacopoeianl
dc.subjectpyrogennl
dc.subjectbacterial endotoxinnl
dc.subjectabnormal toxicity; depressor substancesnl
dc.subjectcalcitoninnl
dc.subjectcorticotrophinnl
dc.subjectglucagon; gonadotrophinnl
dc.subjecthuman growth hormonenl
dc.subjectinsulinnl
dc.subjectoxytocinnl
dc.subjecttetracosactide; high performance liquid chromatographynl
dc.subjectin vitronl
dc.titleAnimal Usage in Quality Control of Pharmaceutical Products: Investigatory literature search for possibilities of replacing, reducing or refining animal experimentationen
dc.title.alternativeHet gebruik van dieren in de kwaliteitscontrole van farmaceutische produkten ; literatuuronderzoek aangaande mogelijkheden voor vervanging, vermindering of verfijning van dierproevennl
dc.typeOnderzoeksrapport
dc.date.updated2012-12-12T19:42:58Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractThe quality standards with which parmaceutical substances have to comply are provided by pharmacopoeias. Traditionally, experiments on animals are required for the assessment of the biological activity of certain pharmaceutical substances, particularly those of natural origin. Furthermore, animal tests are used to ensure the purity and safety of pharmaceutical substances. This report provides an inventory of the state of affairs in refining and/or replacing animal tests traditionally required and applied for the estimation of potency of hormones and hormonal products. Also the status quo of replacing some general safety tests are discussed. It is concluded that over the past few years a clear tendency towards the replacement of traditional in vivo bioassays could be observed. However, the actual introduction of alternatives is only slowly taking place, mainly for lack of information about the validity of such techniques. The report includes suggestions and recommendations with regard to the development, validation and application of alternative methods.


This item appears in the following Collection(s)

Show simple item record