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    Toxicokintetics of lindane (y-HCH) and several PCB congerners in the goat after oral dosing

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    Authors
    Sips AJAM
    Eijkeren JCH van
    Bode W
    Hamzink MRJ
    Klaassen R
    Type
    Report
    Language
    en
    
    Metadata
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    Title
    Toxicokintetics of lindane (y-HCH) and several PCB congerners in the goat after oral dosing
    Translated Title
    Toxicokinetiek van oraal toegediend lindaan (y-HCH) en diverse PCB-congeneren in de geit
    Publiekssamenvatting
    In 1995 is door Olling et al. een methode geintroduceerd om in landbouwhuisdieren te schatten wat de huidige lichaamsbelasting en de dagelijkse opname van een milieucontaminant in het recente verleden is geweest. Deze methode is gebaseerd op slechts enkele metingen in melk, bloed of vet. Het doel van de in dit rapport beschreven studie is deze methode van monstername te valideren en vervolgens hieruit een rekenmodule plus een Graphical User Interface (GUI) te ontwikkelen (zie ook RIVM-rapportnummer 643810005). Ter validatie van de methode is een experiment opgezet waarbij aan geiten hetzij PCBs, hetzij lindaan (y-HCH) is toegediend. Om de kinetiek van de afzondelijke PCBs en lindaan te beschrijven is een PBPK model voor de geit opgesteld. De geschatte standaard fysiologische parameters en de gevonden parameters zijn geomplementeerd in een schattingsmodule. Een deel van de data is vervolgens gebruikt om huidige lichaamsbelasting en dagelijkse absorptie in de geit te schatten. Het blijkt dat de methode goed gebruikt zou kunnen worden als een eerste test om inzicht te krijgen in de contaminatie van een bedrijf.
    In 1995 Olling et al. proposed a method to assess the body burden and daily absorption of a lipophilic contaminant in cattle both prospectively and retrospectively on the basis of only a limited number of measurements in milk, blood or fat. In order to validate the applicability of this method, it was decided to assess its performance by means of an experiment in goats who would receive known amounts of PCB congeners or lindane (y-HCH). Subsequently, contaminant concentrations in plasma and milkfat were measured. These results were incorporated into a PBPK model of the goat in order to describe the kinetics of the individual PCB congeners and lindane. Estimation of kinetic parameters was carried out by fitting them to the data in an automated procedure. The estimated standard physiological parameters of the goat together with the fitted kinetic parameter values have been implemented into an estimation module based on the assessment method. Part of the data has been used to estimate the known body burden and daily absorption. It appears that the method offers a good screening tool for gaining insight into current body burden and recent history of contamination of cattle.
    Description
    Practical use of the results of this report in report 643810005
    Sponsors
    Inspectie W en V
    URI
    http://hdl.handle.net/10029/261540
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