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    The occurrence of Carcinogenic, Mutagenic and Reprotoxic (CMR) substances in consumer preparations

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    Authors
    Muller JJA
    Bos PMJ
    Series/Report no.
    RIVM rapport 320010001
    Type
    Report
    Language
    en
    
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    Title
    The occurrence of Carcinogenic, Mutagenic and Reprotoxic (CMR) substances in consumer preparations
    Translated Title
    Het voorkomen van Carcinogene, Mutagene en Reproductietoxische (CMR-) stoffen in consumentenpreparaten
    Publiekssamenvatting
    The general public is protected from the effects of Carcinogenic, Mutagenic and Reprotoxic (CMR) substances partly by banning the sale of preparations containing classified CMR substances (Annex I of 67/548/EEC) at levels above the limit concentration for exposure of the general public. It is therefore important that consumer preparations are checked for the presence of these substances and that, in addition, potential CMR substances are assessed for inclusion in Annex I of 67/548/EEC. A search was made for potential CMR substances in electronically accessible databases, after which a list of 514 potential CMR substances not found in Annex 1 could be compiled. The occurrence of CMR category 1 and 2 substances, and of additional potential CMR substances, in consumer preparations was checked against the SPIN database, an initiative of the Nordic countries. A total of 146 Annex I substances for the CMR categories 1 and 2, and 24 potential CMR substances were found to be present in consumer preparations used in the Nordic countries. It cannot be ruled out that these substances will also be present in consumer preparations used in the Netherlands. A quantitative estimate of the potential exposure to CMR substances was not possible due to the lack of an adequate database of consumer preparations showing actual concentrations.
    Bescherming van de algemene bevolking tegen de gezondheidsnadelige effecten van Carcinogene, Mutagene en reproductietoxische stoffen wordt voor een belangrijk deel gerealiseerd door een verbod op de verkoop van producten die categorie 1 en 2 CMR-stoffen (Annex I of 67/548/EEC) boven de toegestane limiet bevatten. Het is derhalve belangrijk na te gaan in hoeverre deze stoffen voorkomen in consumenten preparaten en inzicht te verkrijgen in potentiele CMR-stoffen die niet voorkomen op Annex 1. Met behulp van elektronisch toegankelijke databases werd gezocht naar potentiele CMR-stoffen. Dit leverde een additionele lijst van 514 potentiele CMR-stoffen op die niet voorkomen op Annex 1. Het voorkomen van geclassificeerde en potentiele CMR-stoffen in consumentenpreparaten werd geverifieerd aan de hand van het Noord-Europese SPIN databestand. In totaal bleken 146 CMR-stoffen voorkomend op Annex I en 24 potentiele CMR-stoffen voor te komen in consumentenpreparaten. Het kan niet worden uitgesloten dat deze stoffen ook in Nederland kunnen voorkomen in consumenten-preparaten. Aangezien kwantitatieve gegevens over de gehalten van deze stoffen in de betreffende preparaten niet vrij toegankelijk zijn, is een kwantitatieve schatting van de blootstelling niet mogelijk.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    URI
    http://hdl.handle.net/10029/8883
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